Case Report Early administration of steroids for the treatment of drug-induced severe liver and renal injury in a patient with hyperthyroidism

Acute hepatic and renal failure rarely occur simultaneously. Our case is to report the effect of early methylprednisolone treatment on these patients. We describe the clinical presentation, course, and outcome of a 61-yearold man patient with hyperthyroidism, who was treated with methimazole but developed an allergic reaction to the antithyroid drugs that led to pruritus and cholestatic hepatic injury, acute renal injury was found at the same time. Then, suspectible drugs were stopped; methylprednisolone and other symptomatic drugs were given. To monitor the patient’s condition in real time, renal and liver functions were also detected closely. Results: This patient’s renal and liver functions were nearly normal with immediate discontinuation of suspectible drugs and timely administration of methylprednisolone. Our case showed that methylprednisolone could be a possible additional way of treatment for cases with drug-injured severe liver and renal function patients.